Senior Research Fellow, Department of Perinatal Medicine Pregnancy Research Centre
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Dr Rosemary Keogh
BSc (Hons), PhD
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Rosemary completed her PhD at the Department of Medicine (RMH), University of Melbourne in 1997, and then worked overseas in the UK and USA for the next decade. Pursuing research in cardiovascular biology, she has worked on platelet signalling, endothelial and smooth muscle cell biology and monocyte survival. Rosemary is now developing research in the field of cardiovascular reproductive biology, investigating uterine spiral artery remodelling in human pregnancy. This is a continuation of work that she developed at St George’s Hospital Medical School (University of London).
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Rosemary’s interests include:
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- The factors that control fetal trophoblast invasion in to maternal arteries
- The interactions of fetal trophoblast cells with resident vascular cells
- How defects in vessel remodelling during pregnancy lead to complications such as pre-eclampsia and fetal growth restriction
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Current memberships:
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- Australian Society for Medical Research (National Director)
- Australian Society for Biochemistry and Molecular Biology
- Biochemical Society (UK)
- American Society for Investigative Pathology
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Key Publications:
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Hamzic E, Cartwright JE, Keogh RJ, Whitley GS, Greenhill D, Hoppe A.
Live cell image analysis of cell-cell interactions reveals the specific targeting of vascular smooth muscle cells by fetal trophoblasts. Exp Cell Res (2008) 314, 1455-64
Keogh RJ, Harris LK, Freeman A, Baker PN, Aplin JD, Whitley GStJ, Cartwright JE.
Fetal-derived trophoblast utilize the apoptotic cytokine TNF--related apoptosis-inducing ligand (TRAIL) to induce smooth muscle cell death. Circ Res (2007) 100, 834-41
Cartwright JE, Keogh RJ, Tissot van Patot MC.
Hypoxia and placental remodelling. In: Hypoxia and the Circulation. (2007) Eds. R.C. Roach et al., Springer, New York NY. pps 117-30
Harris LK, Keogh, RJ, Wareing, M, Baker PN, Cartwright JE, Whitley GStJ, Aplin JD.
BeWo cells stimulate SMC apoptosis and elastin breakdown in a model of spiral artery transformation. Human Repro (2007) 22, 2834-41
Harris LK*, Keogh RJ*, Wareing M, Baker PN, Cartwright JE, Aplin JD, Whitley GStJ. (* joint first authors)
Invasive trophoblast stimulate vascular smooth muscle cell apoptosis by a Fas ligand-dependent mechanism. Am J Path (2006) 169, 1863-74
Leach L, Badet J, Brownbill P, Harris L, Keogh R, Kalionis B, Whitley G.
Endothelium, blood vessels and angiogenesis - a workshop report. Placenta (2006) 27 Suppl A, 26-29
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